… crystal structures that reveal the crucial interactions made by … As such, it is a target for strand
transfer inhibitors, which are a … high-resolution cocrystal structures of a two-domain HIV-1 IN …

… 3′-processing), binds cellular target DNA and carries out the … The catalytic core domain is
the most stable and conservative … effect on HIV replication, possibly by weakening integrase …

… -1 integrase was shown to commit to substrate DNA within 1 … have implications for the rational
design of HIV-1 IN targeting … (A) Crystal structure of the target capture complex TCC (PDB: …

… Integrase is an attractive target for HIV-1 treatment due to the … Its crystal structure remains
unknown due to the low solubility … owing to its cytotoxic effect. The moieties presented in …

… The complex crystal structure of HTLV-1 integrase (PDB ID = … strength of interactions between
a molecule and its specific target, … The effect of solvent molecules on polar groups, which …

… (NTD) comprising residues 1–46, the catalytic core domain (… strand transfer inhibitors (INSTIs)
have been developed to target … In our study, the structural alteration had no effect on drug …

… target sequence, relative to other templates from prototype foamy viruses. However, crystal
structures … involved in the catalytic activity of the HIV-1 IN catalytic core domain. Several force …

… We describe the functional implications of the acquisition of a … H fold catalytic core flanked
by two DNA-binding domains: … which target DNA disruption by M848 enhances the integrase …

… active compounds or structural complementarity to the target binding site. … While originally
hypothesized to exert their effect through … (A) Crystal structure of tricyclic HIV integrase ROCS …

… Hence, the constraining effect of the β-turn is important for … makes six hydrogen bonds
to the target. NMR studies from the … of interactions of the cyclic peptide with HIV integrase (PDB …